Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis

Author:

Mahmood Abdulrahman Ahmed12345ORCID,Zhang Jianqi12345,Liao Rufang6789,Pan Xiwei12345,Xu Dan6789,Xu Haibo6789,Zhou Qibing12345ORCID

Affiliation:

1. Department of Nanomedicine & Biopharmaceuticals

2. College of Life Science and Technology

3. National Engineering Research Center for Nanomedicine

4. Huazhong University of Science and Technology

5. Wuhan 430074

6. Department of Radiology

7. Zhongnan Hospital of Wuhan University

8. Wuhan 430071

9. China

Abstract

The acid-responsive pHLIP modified SPION as an MRI contrast agent for liver cancer diagnosis requires the validation of both the tumor-specific enhancement and a safe profile in cirrhosis.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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