Precise and long-term tracking of mitochondria in neurons using a bioconjugatable and photostable AIE luminogen

Author:

Park Hojeong1ORCID,Niu Guangle2ORCID,Wu Chao3,Park Chungwon3ORCID,Liu Haixiang4,Park Hyokeun356,Kwok Ryan T. K.14,Zhang Jing1,He Benzhao17,Tang Ben Zhong1849ORCID

Affiliation:

1. Department of Chemistry, Institute for Advanced Study, State Key Laboratory of Neuroscience and Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

2. State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China

3. Division of Life Science, State Key Laboratory of Molecular Neuroscience, HKUST, Clear Water Bay, Kowloon, Hong Kong, China

4. HKUST-Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park, Nanshan, Shenzhen 518057, China

5. Department of Physics, HKUST, Clear Water Bay, Kowloon, Hong Kong, China

6. State Key Laboratory of Molecular Neuroscience, HKUST, Clear Water Bay, Kowloon, Hong Kong, China

7. Center for Advanced Materials Research, Advanced Institute of Natural Sciences, Beijing Normal University at Zhuhai, Zhuhai 519085, China

8. Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, 2001 Longxiang Boulevard, Longgang District, Shenzhen City, Guangdong 518172, China

9. Center for Aggregation-Induced Emission, SCUT-HKUST Joint Research Institute, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China

Abstract

A novel bioconjugatable and photostable AIE luminogen has been rationally synthesized for precise and long-term tracking of neuron mitochondria.

Funder

National Natural Science Foundation of China

Innovation and Technology Commission

Research Grants Council, University Grants Committee

National Key Research and Development Program of China

Shandong University

Taishan Scholar Project of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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