Ratiometric fluorescent probes based on through-bond energy transfer of cyanine donors to near-infrared hemicyanine acceptors for mitochondrial pH detection and monitoring of mitophagy

Author:

Xia Shuai1234,Wang Jianbo12345,Zhang Yibin1234ORCID,Whisman Nick1234,Bi Jianheng1234,Steenwinkel Tessa E.6234,Wan Shulin1234,Medford Jerry1234,Tajiri Momoko1234ORCID,Luck Rudy L.1234ORCID,Werner Thomas6234,Liu Haiying1234ORCID

Affiliation:

1. Department of Chemistry

2. Michigan Technological University

3. Houghton

4. USA

5. College of Biological

6. Department of Biological Sciences

Abstract

Two ratiometric near-infrared fluorescent probes (A and B) have been developed to selectively and accurately detect mitochondrial pH changes based on highly efficient through-bond energy transfer (TBET) from cyanine donors to near-infrared-emissive hemicyanine acceptors.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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