A general and convenient method for the synthesis of 2,4-dinitrobenzyl ketones. Almost unlimited access to 2-substituted 6-nitroindoles from 2,4-dinitrotoluene and aldehydes-Reference-Cited by-同舟云学术

A general and convenient method for the synthesis of 2,4-dinitrobenzyl ketones. Almost unlimited access to 2-substituted 6-nitroindoles from 2,4-dinitrotoluene and aldehydes

Published:2018 Issue:5 Volume:42 Page:3260-3269
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Bujok Robert¹²³^ORCID,Wiszniewski Marcin⁴⁵³^ORCID,Cmoch Piotr¹²³^ORCID,Wróbel Zbigniew¹²³^ORCID

Affiliation:

1. Institute of Organic Chemistry, Polish Academy of Sciences

2. 01-224 Warsaw

3. Poland

4. Faculty of Chemistry, Warsaw University of Technology

5. 00-664 Warsaw

Abstract

Starting from 2,4-dinitrotoluene and aldehydes, 2-substituted 6-nitroindoles with alkyl, cycloalkyl, aryl and heteroaryl (thienyl, furyl, pyridyl) substituents in the 2-position of the indole ring were synthesized. This methodology can be used for synthesis of indoles with non-racemic substituents.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C7NJ04919F

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4. Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons

5. Synthesis and Biological Activity of Novel 4-/5-/6-/7-Nitro-N ′-(4-Aryl-1,3-Thiazol-2-yl)1H-Indole-2-Carbohydrazide Derivatives

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