Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement-Reference-Cited by-同舟云学术

Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement

Published:2017 Issue:6 Volume:19 Page:1454-1461
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Marsini Maurice A.¹²³⁴⁵^ORCID,Buono Frederic G.¹²³⁴⁵,Lorenz Jon C.¹²³⁴⁵,Yang Bing-Shiou¹²³⁴⁵,Reeves Jonathan T.¹²³⁴⁵,Sidhu Kanwar¹²³⁴⁵,Sarvestani Max¹²³⁴⁵,Tan Zhulin¹²³⁴⁵,Zhang Yongda¹²³⁴⁵,Li Ning¹²³⁴⁵,Lee Heewon¹²³⁴⁵,Brazzillo Jason¹²³⁴⁵,Nummy Laurence J.¹²³⁴⁵,Chung J. C.¹²³⁴⁵,Luvaga Irungu K.¹²³⁴⁵,Narayanan Bikshandarkoil A.¹²³⁴⁵,Wei Xudong¹²³⁴⁵,Song Jinhua J.¹²³⁴⁵,Roschangar Frank¹²³⁴⁵,Yee Nathan K.¹²³⁴⁵,Senanayake Chris H.¹²³⁴⁵

Affiliation:

1. Department of Chemical Development

2. Boehringer Ingelheim Pharmaceuticals

3. Inc.

4. Ridgefield

5. USA

Abstract

A convergent and robust synthesis of a developmental CCR1 antagonist is described using continuous flow technology.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry