Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification-Reference-Cited by-同舟云学术

Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification

Published:2017 Issue:6 Volume:6 Page:740-754
ISSN:2045-452X
Container-title:Toxicol. Res.
language:en
Short-container-title:Toxicol. Res.

Author:

Penning Trevor M.¹²³⁴^ORCID

Affiliation:

1. Center of Excellence in Environmental Toxicology and Department of Systems Pharmacology & Translational Therapeutics

2. University of Pennsylvania

3. Philadelphia

4. USA

Abstract

o-Quinones are formed metabolically from natural and synthetic estrogens as well as upon exposure to polycyclic aromatic hydrocarbons (PAH) and contribute to estrogen and PAH carcinogenesis by genotoxic mechanisms.

Funder

National Institute of Environmental Health Sciences

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2017/TX/C7TX00223H

Reference96 articles.

1. Metabolic oxidation of diethylstilbestrol to diethylstilbestrol-4', 4“-quinone in Syrian hamsters

2. Relative rates of 2- and 4-hydroxyestrogen synthesis are dependent on both substrate and tissue

3. Formation of 2- and 4-Hydroxyestrogens by Brain, Pituitary, and Liver of the Human Fetus*

4. The Major Metabolite of Equilin, 4-Hydroxyequilin, Autoxidizes to an o-Quinone Which Isomerizes to the Potent Cytotoxin 4-Hydroxyequilenin-o-quinone

5. Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity

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