Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

Author:

Sun Wan12345,Cui Jing-Xue12345,Ma Le-Le12345,Lu Zhong-Lin12345ORCID,Gong Bing12345,He Lan678,Wang Ruibing91011128ORCID

Affiliation:

1. Key Laboratory of Radiopharmaceuticals

2. Ministry of Education

3. College of Chemistry

4. Beijing Normal University

5. Beijing 100875

6. National Institute for Food and Drug Control

7. Beijing

8. China

9. State Key Laboratory of Quality Research in Chinese Medicine

10. and Institute of Chinese Medical Sciences

11. University of Macau

12. Taipa

Abstract

TP-2Bz, as a nucleus targeting “D–π–A” molecule, was developed as a two-photon turn-on fluorescent probe for the viscosity and GQ DNA detection in cell nuclei.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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