An integrated metabolomics and 16S rRNA gene sequencing approach exploring the molecular pathways and potential targets behind the effects of Radix Scrophulariae-Reference-Cited by-同舟云学术

An integrated metabolomics and 16S rRNA gene sequencing approach exploring the molecular pathways and potential targets behind the effects of Radix Scrophulariae

Published:2019 Issue:57 Volume:9 Page:33354-33367
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lu Fang¹²³⁴,Zhang Ning⁵⁶⁴,Yu Donghua¹²³⁴,Zhao Hongwei²³⁴,Pang Mu²³⁴,Fan Yue⁷²³⁴,Liu Shumin¹²³⁴^ORCID

Affiliation:

1. Institute of Traditional Chinese Medicine

2. Heilongjiang University of Chinese Medicine

3. Harbin 150040

4. PR China

5. Fist Affiliated Hospital of Guizhou University of Traditional Chinese Medicine

6. Guiyang 550001

7. Research Department of Academic Theory

Abstract

An integrated approach to assess impact of caecal microbiota on faecal metabolic phenotypes in the presence of Radix Scrophulariae involving 16S rRNA gene sequencing combined with UHPLC/TOF-MS-based faecal metabolomics was applied to Radix Scrophulariae-treated rats.

Funder

Heilongjiang University of Chinese Medicine

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA03912K

Reference62 articles.

1. Active components from Radix Scrophulariae inhibits the ventricular remodeling induced by hypertension in rats

2. Tenuigenin enhances hippocampal Schaffer collateral-CA1 synaptic transmission through modulating intracellular calcium