Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity-Reference-Cited by-同舟云学术

Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity

Published:2021 Issue:6 Volume:2 Page:1651-1660
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Cundy Nicholas J.¹^ORCID,Hare Roseanna K.²,Tang Tina³,Leach Andrew G.⁴^ORCID,Jowitt Thomas A.⁵,Qureshi Omar³,Gordon John³,Barnes Nicholas M.³⁶,Brady Catherine A.³⁶,Raven Emma L.⁷,Grainger Richard S.¹^ORCID,Butterworth Sam⁴

Affiliation:

1. School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

2. Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK

3. Celentyx Ltd, Birmingham Research Park, 97 Vincent Drive, Birmingham, B15 2SQ, UK

4. Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK

5. Wellcome Trust Centre for Cell Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK

6. Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

7. School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK

Abstract

We report the rational design, novel syntheses and biophysical and in silico evaluation of tryptophan-inspired tool compounds to probe the illusive MOA of the clinically-relevant heme-dioxygenase protein, IDO1.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D0CB00209G

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4. In Vitro and in Vivo Formation of Two New Metabolites of Melatonin

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