Hydrangenol, an active constituent of Hydrangea serrata (Thunb.) Ser., ameliorates colitis through suppression of macrophage-mediated inflammation in dextran sulfate sodium-treated mice

Author:

Kim Su-yeon123,Chung Kyung-Sook1,Jang Seo-Yun14,Han Hee-Soo12,Heo So-Won15,Lee Jong Kil346,Kim Hyoung Ja7,Shin Yu-Kyong8,Ahn Hye Shin8,Lee Sun Hee8,Lee Kyung-Tae123ORCID

Affiliation:

1. Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea

2. Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea

3. Neurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea

4. Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

5. Department of Biomedical and Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea

6. Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea

7. Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Hwarangno 14 gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea

8. Department of New Material Development, COSMAXBIO, Gyeonggi, 13486, Republic of Korea

Abstract

Ulcerative colitis (UC) is a chronic disease of the colon characterized by mucosal damage and relapsing gastrointestinal inflammation.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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