Bioisosteric-replacement-driven optimization of 4-methoxynaphthalene-N-acylhydrazones with anti-Paracoccidioides activity

Author:

Oliveira Amanda Alves de12ORCID,Silva Lívia do Carmo2ORCID,Rozada Andrew Matheus Frederico3,Costa Vinícius Alexandre Fiaia4,Soares Célia Maria de Almeida2,Seixas Flavio Augusto Vicente5ORCID,Neves Bruno Junior4,Gauze Gisele Freitas3,Pereira Maristela2

Affiliation:

1. Institute of Tropical Pathology and Public Health, Federal University of Goiás, CEP: 74605-050, Goiânia, Goiás, Brazil

2. Laboratory for Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Avenida Esperança, s/n, ICB2, Sala 206, Goiânia, GO, CEP: 74690-900, Goiânia, Goiás, Brazil

3. Chemistry Department, State University of Maringá, 87020-900, Maringá, Paraná, Brazil

4. LabChem – Laboratory of Cheminformatics, Faculty of Pharmacy, Federal University of Goiás, 74605-170, Goiânia, Goiás, Brazil

5. Department of Technology, State University of Maringá, 87506-370, Umuarama, Paraná, Brazil

Abstract

Overall workflow employed in this work.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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