One-pot, three-component approach to diarylacetonitriles

Author:

Singh Dileep Kumar1234,Prasad Sure Siva1234,Kim Jinhwang1234,Kim Ikyon1234ORCID

Affiliation:

1. College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences

2. Yonsei University

3. Incheon

4. Republic of Korea

Abstract

Described herein is a novel one-pot, three-component reaction where aldehydes, electron-rich arenes, and TMSCN in the presence of BF3-OEt2 allowed direct access to a number of diarylacetonitriles under mild reaction conditions in good to excellent yields.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference56 articles.

1. Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity

2. Chemistry and Biology Of Multicomponent Reactions

3. Higher-order multicomponent reactions: beyond four reactants

4. Multicomponent Reactions in Organic synthesis , ed. J. Zhu , Q. Wang and M.-X. Wang , Wiley-VCH , Weinheim, Germany , 2015

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