Systematic characterization of metabolic profiles of ingenol in rats by UPLC-Q/TOF-MS and NMR in combination with microbial biotransformation-Reference-Cited by-同舟云学术

Systematic characterization of metabolic profiles of ingenol in rats by UPLC-Q/TOF-MS and NMR in combination with microbial biotransformation

Published:2021 Issue:60 Volume:11 Page:37752-37759
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xiao Si-Jia¹^ORCID,Li Shan-Shan²,Xie Bin¹,Chen Wei¹,Xu Xi-Ke¹,Zu Xian-Peng¹,Shen Yun-Heng¹^ORCID

Affiliation:

1. Department of Natural Medicinal Chemistry, School of Pharmacy, Naval Medical University, Shanghai 200433, China

2. School of Pharmaceutical Sciences, Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, Yunnan, China

Abstract

A total of 18 metabolites were identified in rat, and reference standards of metabolites (M2–M4) were further obtained by biotransformation of ingenol. Hydroxylation, oxygenation, sulfonation, and glucuronidation were major metabolic pathways.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

National Science and Technology Major Project

Shanghai Municipal Health Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA07915H

Reference28 articles.

1. Ingenol Protects Human T Cells From HIV-1 Infection

2. Ingenol Mebutate: A Promising Treatment for Actinic Keratoses and Nonmelanoma Skin Cancers

3. Ingenol Mebutate: A Succinct Review of a Succinct Therapy

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