Divalent metal ions control activity and inhibition of protein kinases
Author:
Affiliation:
1. Department of Biochemistry, University of Kassel
2. 34132 Kassel
3. Germany
4. Biaffin GmbH and Co KG
5. Department of Pharmacology, University of California, San Diego
6. La Jolla
7. USA
Abstract
Metals like Zn2+ and Mn2+ can assist in the catalytic cycle of a protein kinase by facilitating substrate binding and phosphotransfer, however, in contrast to Mg2+ they also hamper product release.
Funder
Michael J. Fox Foundation for Parkinson's Research
Deutsche Forschungsgemeinschaft
Publisher
Oxford University Press (OUP)
Subject
Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2017/MT/C7MT00204A
Reference43 articles.
1. Cellular transport and homeostasis of essential and nonessential metals
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4. Metal ions in biological catalysis: from enzyme databases to general principles
5. Price To Be Paid for Two-Metal Catalysis: Magnesium Ions That Accelerate Chemistry Unavoidably Limit Product Release from a Protein Kinase
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