Development of tumor-targeting aza-vesamicol derivatives with high affinity for sigma receptors for cancer theranostics-Reference-Cited by-同舟云学术

Development of tumor-targeting aza-vesamicol derivatives with high affinity for sigma receptors for cancer theranostics

Published:2022 Issue:8 Volume:13 Page:986-997
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Mishiro Kenji¹^ORCID,Wang Mengfei²,Hirata Saki²,Fuchigami Takeshi²^ORCID,Shiba Kazuhiro³,Kinuya Seigo⁴,Ogawa Kazuma¹²^ORCID

Affiliation:

1. Institute for Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan

2. Graduate School of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan

3. Research Center for Experimental Modeling of Human Disease, Kanazawa University, Takara-machi, Kanazawa, Ishikawa 920-8640, Japan

4. Department of Nuclear Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Takara-machi, Kanazawa, Ishikawa 920-8641, Japan

Abstract

[125I]15 and [125I]17 exhibited high uptake in the tumor and low uptake in non-target tissues, indicating that [123/131I]15 and [123/131I]17 are promising compounds to be used as imaging and therapeutic probes for sigma receptor-positive tumors.

Funder

Takeda Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00099G

Reference51 articles.

1. Syntheses and evaluation of a homologous series of aza-vesamicol as improved radioiodine-labeled probes for sigma-1 receptor imaging

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3. The Molecular Function of σ Receptors: Past, Present, and Future

4. Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs

5. Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases

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