Improving the knock-in efficiency of the MOF-encapsulated CRISPR/Cas9 system through controllable embedding structures-Reference-Cited by-同舟云学术

Improving the knock-in efficiency of the MOF-encapsulated CRISPR/Cas9 system through controllable embedding structures

Published:2021 Issue:39 Volume:13 Page:16525-16532
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Liu Chang¹²,Xu Xiaoyu¹²,Koivisto Oliver¹²,Zhou Wenhui¹²³,Jacquemet Guillaume²⁴⁵,Rosenholm Jessica M.¹,Zhang Hongbo¹²⁶^ORCID

Affiliation:

1. Pharmaceutical Sciences Laboratory, Åbo Akademi University, Turku 20520, Finland

2. Turku Bioscience Centre, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland

3. Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China

4. Faculty of Science and Engineering, Cell biology, Åbo Akademi University, FI-20520 Turku, Finland

5. Turku Bioimaging, University of Turku and Åbo Akademi University, 20520 Turku, Finland

6. Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, P. R. China

Abstract

A rapid and convenient method was developed to load gene molecules into nanostructures, exploring structure–function relationship for efficient intracellular delivery and gene editing, opening up new avenues for the MOF-based non-viral vectors.

Funder

Biocenter Finland

National Natural Science Foundation of China

Academy of Finland

Sigrid Juséliuksen Säätiö

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D1NR02872C

Reference40 articles.