Ibuprofen transport in renal cell cultures: characterization of an ibuprofen transporter upregulated by hyperosmolarity-Reference-Cited by-同舟云学术

Ibuprofen transport in renal cell cultures: characterization of an ibuprofen transporter upregulated by hyperosmolarity

Published:2016 Issue:10 Volume:7 Page:1916-1924
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Rasmussen Rune Nørgaard¹²³⁴,Holm René⁵⁶⁷⁸⁹,Christensen Kenneth Vielsted¹⁰¹¹⁴,Nielsen Carsten Uhd¹²³⁴^ORCID

Affiliation:

1. Department of Physics, Chemistry and Pharmacy

2. University of Southern Denmark

3. DK-5230 Odense M

4. Denmark

5. Drug Product Development

6. Janssens Research and Development

7. Johnson & Johnson

8. 2430 Beerse

9. Belgium

10. Drug Discovery Neuroscience

11. DK-2500 Valby

Abstract

An ibuprofen transporter localizes to the apical and basolateral membrane of MDCK I cells is upregulated by hyperosmotic exposure. Ibuprofen uptake is inhibited by other NSAIDs and ibuprofen metabolites.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00305B

Reference31 articles.

1. The Metabolism of Ibuprofen

2. Clinical Pharmacokinetics of Ibuprofen

3. Brain Uptake of Nonsteroidal Anti-Inflammatory Drugs: Ibuprofen, Flurbiprofen, and Indomethacin

4. Interactions of Human Organic Anion Transporters and Human Organic Cation Transporters with Nonsteroidal Anti-Inflammatory Drugs

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Transcriptome analysis identifies activated signaling pathways and regulated ABC transporters and solute carriers after hyperosmotic stress in renal MDCK I cells;Genomics;2019-12

2. Nfat5 is involved in the hyperosmotic regulation of Tmem184b: a putative modulator of ibuprofen transport in renal MDCK I cells;FEBS Open Bio;2019-05-07