8-Oxo-7,8-dihydro-2′-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA-Reference-Cited by-同舟云学术

8-Oxo-7,8-dihydro-2′-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA

Published:2017 Issue:39 Volume:15 Page:8341-8353
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Fleming Aaron M.¹²³⁴,Burrows Cynthia J.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Utah

3. Salt Lake City

4. USA

Abstract

8-Oxo-2′-deoxyguanosine in a tandem lesion context is two orders of magnitude more susceptible to oxidation than in a context of native DNA yielding hydantoin products.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB02096A

Reference74 articles.

1. Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates

2. How Easily Oxidizable Is DNA? One-Electron Reduction Potentials of Adenosine and Guanosine Radicals in Aqueous Solution

3. Stress appraisals and cellular aging: A key role for anticipatory threat in the relationship between psychological stress and telomere length