Design, synthesis andin vitroα-glucosidase inhibition of novel coumarin-pyridines as potent antidiabetic agents

Author:

Adib Mehdi123ORCID,Peytam Fariba123,Rahmanian-Jazi Mahmoud123,Mohammadi-Khanaposhtani Maryam453,Mahernia Shabnam62372,Bijanzadeh Hamid Reza823,Jahani Mehdi123,Imanparast Somaye923,Faramarzi Mohammad Ali923,Mahdavi Mohammad1023,Larijani Bagher1023

Affiliation:

1. School of Chemistry, College of Science, University of Tehran

2. Tehran

3. Iran

4. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences

5. Babol

6. Department of Medicinal Chemistry, Drug Design and Development Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences

7. Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences, Tehran University of Medical Sciences

8. Environmental Science Department, Faculty of Natural Resources and Marine Sciences, Tarbiat Modares University

9. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences

10. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences

Abstract

Herein, novel coumarin-pyridine derivatives4a–pas potent α-glucosidase inhibitors were synthesized by a one-pot and three-component synthesis method.

Funder

University of Tehran

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference49 articles.

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