A sandwich SERS immunoassay platform based on a single-layer Au–Ag nanobox array substrate for simultaneous detection of SCCA and survivin in serum of patients with cervical lesions

Author:

Liu Yifan123,Ran Menglin23,Sun Yue145,Fan Yongxin145,Wang Jinghan3,Cao Xiaowei145ORCID,Lu Dan1234

Affiliation:

1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, P. R. China

2. Department of Obstetrics and Gynecology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, P. R. China

3. The Yangzhou School of Clinial Medicine of Dalian Medical University, Yangzhou, P. R. China

4. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou, P. R. China

5. Jiangsu Key Laboratory of Experimental & Translational Noncoding RNA Research, Medical College, Yangzhou University, Yangzhou 225001, China

Abstract

A novel SERS immunoassay platform for simultaneous detection of SCCA and survivin based on Au–Ag nanoshells (Au–AgNSs) combined with a single-layer Au–AgNB array substrate was proposed in the current study.

Funder

National Natural Science Foundation of China

Social Science Foundation of Jiangsu Province

Natural Science Research of Jiangsu Higher Education Institutions of China

YangZhou Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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