Synthesis of isolable β-chloroenamines from <i>N</i>-alkoxylactams with organometallic reagents-Reference-Cited by-同舟云学术

Synthesis of isolable β-chloroenamines from N-alkoxylactams with organometallic reagents

Published:2023 Issue:7 Volume:21 Page:1435-1439
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Takeda Norihiko¹^ORCID,Suganuma Riku¹,Yasui Motohiro¹^ORCID,Ueda Masafumi¹^ORCID

Affiliation:

1. Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan

Abstract

An efficient approach to access isolable β-chloroenamines via nucleophilic addition/dehydration of α-chloro N-alkoxylactam with organolithium and Grignard reagents is reported.

Funder

Japan Society for the Promotion of Science

Mitsubishi Tanabe Pharma Corporation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02151J

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3. Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides

4. Flexible access to 2,3,5,6-tetrasubstituted dehydropiperidines by Ni- or Co-catalyzed site-selective cross-coupling using Vilsmeier-Haack-derived α-chloro-β-formyltetrahydropyridines

5. Convergent and Stereoselective Method for the Synthesis of Acyclic α-Chloroenamides

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