Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA-Reference-Cited by-同舟云学术

Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA

Published:2019 Issue:7 Volume:17 Page:1778-1786
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Patwardhan Neeraj N.¹²³^ORCID,Cai Zhengguo¹²³^ORCID,Newson Colby N.¹²³,Hargrove Amanda E.¹²³^ORCID

Affiliation:

1. Department of Chemistry, 124 Science Drive

2. Box 90346

3. USA

Abstract

A fluorescent peptide displacement assay combined with statistical analysis is used for screening small molecules against different RNA targets and profiling their affinity/selectivity patterns.

Funder

Duke University

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02467G

Reference67 articles.

1. The Emerging Role of RNA as a Therapeutic Target for Small Molecules

2. RNA as a small molecule druggable target

3. Targeting RNA in mammalian systems with small molecules

4. Targeting RNA with Small Molecules

5. Small molecules targeting viral RNA

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