Bimetallic nanoplatform for synergistic sonodynamic-calcium overload therapy utilizing self-supplied hydrogen peroxide and relieved hypoxia-Reference-Cited by-同舟云学术

Bimetallic nanoplatform for synergistic sonodynamic-calcium overload therapy utilizing self-supplied hydrogen peroxide and relieved hypoxia

Published:2024 Issue: Volume: Page:
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Xu Wenqian¹^ORCID,Zhao Yisheng²,Zhang Chao³,Huo Mengping¹,Wang Lei¹,Wu Xuewu⁴,Zhang Yang¹,Li Qiao¹,Gai Yonghao¹

Affiliation:

1. Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, P.R. China

2. School of Pharmaceutical Sciences, Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, P.R. China

3. Department of Pediatrics, Qilu Hospital of Shandong University, Jinan 250012, P.R. China

4. Department of Urology, The Second Hospital of Lanzhou University, Gansu Nephro-Urological Clinical Center, Lanzhou 730000, P.R. China

Abstract

This study introduces a bimetallic nanoplatform (Fe3O4-TAPP@PVP-CaO2) that addresses the limitations in sonodynamic therapy. It enhances oxygen supply, generates toxic reactive oxygen species, and triggers cancer cell death through calcium overload.

Funder

Qilu University of Technology

National Natural Science Foundation of China

Taishan Scholar Project of Shandong Province

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D3BM01430D

Reference54 articles.