Design, synthesis and biological evaluation of a halogenated phenazine-erythromycin conjugate prodrug for antibacterial applications-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of a halogenated phenazine-erythromycin conjugate prodrug for antibacterial applications

Published:2021 Issue:7 Volume:19 Page:1483-1487
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yang Hongfen¹²³⁴⁵,Liu Ke¹²³⁴⁵^ORCID,Jin Shouguang⁶⁷⁵⁸⁹,Huigens III Robert W.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. Center for Natural Products

3. Drug Discovery and Development (CNPD3)

4. College of Pharmacy

5. University of Florida

6. Department of Molecular Genetics & Microbiology

7. College of Medicine

8. Gainesville

9. USA

Abstract

We report the synthesis and initial biological assessment of a halogenated phenazine–erythromycin conjugate prodrug 5 aimed to treat bacterial infections.

Funder

National Institute of General Medical Sciences

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02428G

Reference22 articles.

1. The Science of Antibiotic Discovery

2. Platforms for antibiotic discovery

3. Antibacterial drug discovery in the resistance era

4. Endless resistance. Endless antibiotics?

5. Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance

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