Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth-Reference-Cited by-同舟云学术

Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth

Published:2024 Issue:17 Volume:22 Page:3425-3438
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Vaaland Holmgard I. Caroline¹,González-Bakker Aday²,Poeta Eleonora³,Puerta Adrián²,Fernandes Miguel X.⁴^ORCID,Monti Barbara³,Fernández-Bolaños José G.⁵^ORCID,Padrón José M.²,López Óscar⁵^ORCID,Lindbäck Emil¹^ORCID

Affiliation:

1. Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway

2. BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Universidad de La Laguna, c/Astrofísico Francisco Sánchez 2, La Laguna, E-38206, Spain

3. Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

4. Department of Engineering and Chemical Sciences, Karlstad University, Karlstad, Sweden

5. Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Seville, Spain

Abstract

Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro and no neurotoxicity.

Funder

Agencia Estatal de Investigación

Agencia Canaria de Investigación, Innovación y Sociedad de la Información

Fundación Científica Asociación Española Contra el Cáncer

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00312H

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