Organic small molecule for detection and photodegradation of mitochondrial DNA mutations-Reference-Cited by-同舟云学术

Organic small molecule for detection and photodegradation of mitochondrial DNA mutations

Published:2019 Issue:39 Volume:7 Page:5947-5955
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Su Chien-Hui¹²³⁴,Chen Jyun-Wei⁵²³⁴,Chen Li-Da¹²³⁴,Chang Jui-Chih⁶⁷⁸⁴,Liu Chin-San⁶⁷⁸⁴,Chang Cheng-Chung⁵²³⁴^ORCID,Wang Gou-Jen¹²³⁴⁵^ORCID

Affiliation:

1. Department of Mechanical Engineering

2. National Chung-Hsing University

3. Taichung

4. Taiwan

5. Graduate Institute of Biomedical Engineering

6. Vascular and Genomic Research Center

7. Changhua Christian Hospital

8. Changhua

Abstract

Mitochondrial localization photosensitizer NV-12P may recognize 8-oxo-dG with PET and FRET mechanism. Furthermore, NV-12P can generate a reactive oxygen species to degrade 8-oxo-dG using a similar mechanism of methyl blue.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2019/TB/C9TB01358J

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