Biological promiscuity of a binuclear Cu(ii) complex of aminoguanidine Schiff base: DNA binding, anticancer activity and histidine sensing ability of the complex

Author:

Mondal Antu1234ORCID,Das Chandrima1234,Corbella Montse56789ORCID,Bauzá Antonio11011129ORCID,Frontera Antonio11011129ORCID,Saha Moumita131415164,Mondal Sanchaita131415164,Das Saha Krishna131415164ORCID,Chattopadhyay Shyamal Kumar1234ORCID

Affiliation:

1. Department of Chemistry

2. Indian Institute of Engineering Science and Technology

3. Howarh-711 103

4. India

5. Department of Inorganic Chemistry

6. University of Barcelona

7. MartíiFranquès 1-11

8. 08028 Barcelona

9. Spain

10. University of the Balearic Islands

11. Carretera de Valldemossa km 7.5

12. 07122 Palma de Mallorca

13. Cancer Biology and Inflammatory Disorder Division

14. CSIR-Indian Institute of Chemical Biology

15. 4, Raja S.C. Mullick Road

16. Kolkata-700032

Abstract

A binuclear Cu(ii) complex of aminoguanidine shows strong DNA binding activity and encouraging anti-cancer activity against HCT-16 cells. The complex can also be used for selective spectrophotomteric or fluorometric determination of histidine.

Funder

Department of Science and Technology, Government of West Bengal

Indian Institute of Engineering Science and Technology, Shibpur

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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