A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution

Author:

Coverdale James P. C.1234ORCID,Barnett James P.5674ORCID,Adamu Adamu H.1234,Griffiths Ellie J.1234,Stewart Alan J.89104ORCID,Blindauer Claudia A.1234ORCID

Affiliation:

1. Department of Chemistry

2. University of Warwick

3. Coventry

4. UK

5. Department of Life Sciences

6. Birmingham City University

7. Edgbaston

8. School of Medicine

9. University of St Andrews

10. St Andrews

Abstract

Serum albumin is the major zinc carrier in blood plasma. Fatty acid binding to albumin regulates its zinc-binding ability and alters plasma zinc speciation.

Funder

Biotechnology and Biological Sciences Research Council

Leverhulme Trust

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

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