Ultrasensitive amplification-free detection of circulating miRNA <i>via</i> droplet-based processing of SERS tag–miRNA–magnetic nanoparticle sandwich nanocomplexes on a paper-based electrowetting-on-dielectric platform-Reference-Cited by-同舟云学术

Ultrasensitive amplification-free detection of circulating miRNA via droplet-based processing of SERS tag–miRNA–magnetic nanoparticle sandwich nanocomplexes on a paper-based electrowetting-on-dielectric platform

Published:2024 Issue:7 Volume:149 Page:1981-1987
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Wang Kai-Hao¹,Chen Yuan-Yu¹,Wang Chih-Hsien¹,Hsu Keng-Fu²,Chau Lai-Kwan¹^ORCID,Wang Shau-Chun¹^ORCID,Chen Yuh-Ling³

Affiliation:

1. Department of Chemistry and Biochemistry and Center for Nano Bio-Detection, National Chung Cheng University, Chia-Yi 62102, Taiwan

2. Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan 70101, Taiwan

3. Institute of Oral Medicine, National Cheng Kung University, Tainan 70101, Taiwan

Abstract

Rapid (∼5 min) pretreatment and concentration of the MNP–miRNA–NAEB complex are accomplished using a pEWOD device. This facilitates sub-femtomolar SERS detection for analyzing microRNA in clinical samples of ovarian cancer.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D3AN01429K

Reference54 articles.

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3. MicroRNAs in cancer therapeutics: “from the bench to the bedside”

4. Clinical relevance of circulating cell-free microRNAs in cancer

5. Ovarian cancer statistics, 2018

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