Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity-Reference-Cited by-同舟云学术

Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity

Published:2022 Issue:11 Volume:9 Page:2594-2607
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Marloye Mickaël¹,Inam Haider²,Moore Connor J.²,Mertens Tyler R.³,Ingels Aude⁴,Koch Marilin⁵,Nowicki Michal O.⁵,Mathieu Véronique⁴⁶,Pritchard Justin R.²,Awuah Samuel G.³^ORCID,Lawler Sean E.⁵,Meyer Franck¹^ORCID,Dufrasne François¹,Berger Gilles¹⁵^ORCID

Affiliation:

1. Microbiology, Bioorganic & Macromolecular Chemistry Unit, Faculté de Pharmacie, Université libre de Bruxelles (ULB), Boulevard du Triomphe, 1050 Brussels, Belgium

2. Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA

3. Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA

4. Department of Pharmacotherapy and Pharmaceutics, Faculté de Pharmacie, Université libre de Bruxelles (ULB), Boulevard du Triomphe, 1050 Brussels, Belgium

5. Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA

6. ULB Cancer Research Center (UCRC), Université libre de Bruxelles (ULB), 1050 Brussels, Belgium

Abstract

Amphiphilic ruthenium and osmium complexes auto-assemble to nanosystems that poison mitochondria and show highly promisingin vitroandin vivoanticancer activity.

Funder

Fédération Wallonie-Bruxelles

Belgian Brain Tumor Support

Fonds De La Recherche Scientifique - FNRS

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QI/D2QI00423B

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1. Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode