Activation of perfluoroalkyl iodides by anions: extending the scope of halogen bond activation to C(sp<sup>3</sup>)–H amidation, C(sp<sup>2</sup>)–H iodination, and perfluoroalkylation reactions-Reference-Cited by-同舟云学术

Activation of perfluoroalkyl iodides by anions: extending the scope of halogen bond activation to C(sp³)–H amidation, C(sp²)–H iodination, and perfluoroalkylation reactions

Published:2023 Issue:7 Volume:14 Page:1732-1741
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Yaxin¹²,Cao Zehui¹,He Qin¹,Huang Xin³,Liu Jiaxi¹,Neumann Helfried²^ORCID,Chen Gong³^ORCID,Beller Matthias²^ORCID

Affiliation:

1. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

2. Leibniz-Institute for Catalysis, Albert-Einstein-Str. 29a, Rostock 18059, Germany

3. State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Abstract

A simple activation of perfluoroalkyl iodides by tBuONa or KOH allows the promotion of α-sp3 C–H amidation reactions of alkyl ethers and benzylic hydrocarbons, C–H iodination of heteroaryl compounds, and perfluoroalkylations of electron-rich π bonds.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Nanjing University of Chinese Medicine

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC06145G

Reference107 articles.