A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display-Reference-Cited by-同舟云学术

A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display

Published:2019 Issue:61 Volume:55 Page:8959-8962
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Iqbal Emil S.¹²³⁴⁵^ORCID,Richardson Stacie L.¹²³⁴⁵,Abrigo Nicolas A.¹²³⁴⁵,Dods Kara K.¹²³⁴⁵^ORCID,Osorio Franco H. Estheban¹²³⁴⁵,Gerrish Heather S.¹²³⁴⁵,Kotapati Hari Kiran⁶⁷⁸⁴^ORCID,Morgan Iain M.⁵²³⁴⁹,Masterson Douglas S.⁶⁷⁸⁴,Hartman Matthew C. T.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Virginia Commonwealth University

3. Richmond

4. USA

5. Massey Cancer Center

6. School of Mathematics & Natural Sciences

7. Chemistry & Biochemistry

8. Hattiesburg

9. Philips Institute for Oral Health Research

Abstract

α-methyl Cys incorporation plus cyclization allows for the creation of α-helical libraries by mRNA display.

Funder

National Cancer Institute

National Center for Advancing Translational Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C8CC10192B

Reference45 articles.

1. Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

2. State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors

3. Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors

4. Assessing Helical Protein Interfaces for Inhibitor Design

5. Constrained peptides' time to shine?

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