Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity-Reference-Cited by-同舟云学术

Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity

Author:

Chan Alex H. Y.¹,Fathoni Imam²,Ho Terence C. S.¹³,Saliba Kevin J.²^ORCID,Leeper Finian J.¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

2. Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia

3. Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK

Abstract

A series of derivatives of a triazole analogue of thiamine has been synthesised.

Funder

Australian Government

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

Reference21 articles.

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