Combining biomimetic collagen/hyaluronan hydrogels with discogenic growth factors promotes mesenchymal stroma cell differentiation into Nucleus Pulposus like cells-Reference-Cited by-同舟云学术

Combining biomimetic collagen/hyaluronan hydrogels with discogenic growth factors promotes mesenchymal stroma cell differentiation into Nucleus Pulposus like cells

Published:2023 Issue:24 Volume:11 Page:7768-7783
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Okoro Prince David¹,Frayssinet Antoine¹,De Oliveira Stéphanie¹,Rouquier Léa²,Miklosic Gregor³^ORCID,D'Este Matteo³,Potier Esther²,Hélary Christophe¹^ORCID

Affiliation:

1. Laboratoire de Chimie de la Matière Condensée de Paris, Sorbonne Université, CNRS, UMR 7574, F-75005, Paris, France

2. Université Paris Cité, CNRS, INSERM, ENVA, B3OA, F-75010 Paris, France

3. AO Research Institute Davos (ARI), Clavadelerstrasse 8, 7270 Davos, Switzerland

Abstract

The combination of discogenic factors with biomimetic collagen/hyaluronan hydrogels is promising for disc regeneration; a high content of hyaluronan is responsible for the BM-MSC differentiation into NP like cells.

Funder

Agence Nationale de la Recherche

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D3BM01025B

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