Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines-Reference-Cited by-同舟云学术

Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines

Published:2018 Issue:44 Volume:16 Page:8546-8552
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Biyun¹²³⁴⁵,Zhao Xianghu¹²³⁴⁵,Liu Qingyun¹²³⁴⁵,Cao Song¹²³⁴⁵^ORCID

Affiliation:

1. Shanghai Key Laboratory of Chemical Biology

2. School of Pharmacy

3. East China University of Science and Technology (ECUST)

4. Shanghai 200237

5. China

Abstract

A novel and efficient method for the synthesis of arylacetamides by the reactions of gem-difluoroalkenes with N,N-dialkylformamides, and primary and secondary amines with the assistance of KOtBu and water was developed.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02322K

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