Using a systematic and quantitative approach to generate new insights into drug loading of PLGA nanoparticles using nanoprecipitation

Author:

Hamdallah Sherif I.12ORCID,Zoqlam Randa3,Yang Bin4,Campbell Andrew4,Booth Rebecca5,Booth Jonathan5,Belton Peter6,Qi Sheng1ORCID

Affiliation:

1. School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK

2. Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

3. School of Pharmacy, University College London, London WC1N 1AX, UK

4. Advanced Drug Delivery, Pharmaceutical Sciences, The Discovery Center (DISC), 1 Francis Crick Avenue, Cambridge, CB2 0AA, UK

5. New Modalities and Parenteral Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, UK

6. School of Chemistry, University of East Anglia, Norwich NR4 7TJ, UK

Abstract

An exploratory investigation into the molecular-level determinants influencing efficient drug loading in PLGA nanoparticles using a nanoprecipitation method.

Publisher

Royal Society of Chemistry (RSC)

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