Does thermotropic liquid crystalline self-assembly control biological activity in amphiphilic amino acids? – tyrosine ILCs as a case study

Author:

Grunwald Marco André1,Hagenlocher Selina Emilie1,Turkanovic Larissa1,Bauch Soeren Magnus1,Wachsmann Sebastian Benedikt1,Altevogt Luca Alexa1,Ebert Max1,Knöller Julius Agamemnon1,Raab Aileen Rebecca1ORCID,Schulz Finn1,Kolmangadi Mohamed A.2,Zens Anna1ORCID,Huber Patrick345ORCID,Schönhals Andreas2ORCID,Bilitiewski Ursula6,Laschat Sabine1ORCID

Affiliation:

1. Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany

2. Bundesanstalt für Materialforschung und-prüfung (BAM), D-12205 Berlin, Germany

3. Institute for Materials and X-Ray Physics, Hamburg University of Technology, D-21073 Hamburg, Germany

4. Centre for X-ray and Nano Science CXNS, Deutsches Elektronen-Synchrotron DESY, D-22605 Hamburg, Germany

5. Centre for Hybrid Nanostructures ChyN, University Hamburg, D-21073 Hamburg, Germany

6. AG Compound Profiling and Screening, Helmholtz Zentrum für Infektionsforschung, Inhoffenstr. 7, D-38124 Braunschweig, Germany

Abstract

A series of modular combinations ofl-tyrosine and substituted benzoic acids was studied to understand their mesomorphic behavior and to establish a possible link between liquid crystalline properties and biological activity of these new compounds.

Funder

Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg

Fonds der Chemischen Industrie

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

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