Asymmetric amination of α,α-dialkyl substituted aldehydes catalyzed by a simple chiral primary amino acid and its application to the preparation of a S1P1 agonist-Reference-Cited by-同舟云学术

Asymmetric amination of α,α-dialkyl substituted aldehydes catalyzed by a simple chiral primary amino acid and its application to the preparation of a S1P1 agonist

Published:2019 Issue:57 Volume:9 Page:33497-33505
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xiao Qiong¹²³⁴⁵^ORCID,Tang Yifan⁶⁷,Xie Ping¹²³⁴⁵,Yin Dali¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines

2. Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation

3. Department of Medicinal Chemistry

4. Institute of Materia Medica

5. Peking Union Medical College

6. Beijing Union Pharmaceutical Factory

7. PR China

Abstract

The chiral catalytic amination of an α,α-dialkyl substituted aldehyde usually proceeds with low enantioselectivity.

Funder

National Basic Research Program of China

Chinese Academy of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA06210F

Reference24 articles.

1. The C-Terminal Heptapeptides of Suzukacillin A and Alamethicin F30 — Sequence, Conformation, and Synthesis

2. Structural elucidation of trikoningins KA and KB, peptaibols from Trichoderma koningii

3. Harzianin HB I, an 11-residue peptaibol from Trichoderma harzianum: isolation, sequence, solution synthesis and membrane activity

4. Asymmetrische katalytische Aminoalkylierungen: neue leistungsstarke Methoden zur enantioselektiven Synthese von Aminosäurederivaten, Mannich-Basen und Homoallylaminen

5. From Styrenes to Enantiopure α-Arylglycines in Two Steps

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