One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp3)

One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp3)–H activations

Published:2017 Issue:9 Volume:53 Page:1534-1537
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yang Xinglin¹²³⁴⁵,Shan Gang¹²³⁴⁵,Yang Zimo¹²³⁴⁵,Huang Guiyi¹²³⁴⁵,Dong Guoqiang⁶⁷⁸⁵,Sheng Chunquan⁶⁷⁸⁵,Rao Yu¹²³⁴⁵^ORCID

Affiliation:

1. MOE Key Laboratory of Protein Sciences

2. School of Pharmaceutical Sciences

3. Tsinghua University

4. Beijing 100084

5. China

6. School of Pharmacy

7. Second Military Medical University

8. Shanghai 200433

Abstract

A novel approach toward quaternary carbon centered cyclobutanes through Pd(ii)-catalyzed sequential intramolecular methylene C–H alkylation and intermolecular methine C–H bond arylation, alkenylation, alkylation, alkynylation, allylation, benzylation or alkoxylation is described.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC06897A

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