Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor-Reference-Cited by-同舟云学术

Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor

Author:

Hugentobler Katharina G.¹²³⁴⁵,Sharif Humera¹²³⁴⁵,Rasparini Marcello⁶⁷⁸⁹¹⁰,Heath Rachel S.¹²³⁴⁵,Turner Nicholas J.¹²³⁴⁵

Affiliation:

1. School of Chemistry

2. University of Manchester

3. Manchester Institute of Biotechnology

4. Manchester M1 7DN

5. UK

6. Chemessentia Srl.

7. Via G. Bovio 6 – 28100 Novara

8. Italy

9. Janssen Pharmaceutica API small molecule development

10. B-2340 Beerse

Abstract

Three different enzymatic routes were employed to produce a precursor of the important antithrombotic agent Ticagrelor with high ee.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

Reference13 articles.

1. P. T. Anastas and J. C.Warner, Green Chemistry: Theory and Practice, Oxford University Press, New York, 1998, p. 30

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