First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins-Reference-Cited by-同舟云学术

First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins

Published:2023 Issue:84 Volume:59 Page:12641-12644
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

O’Dowd Paul D.¹²^ORCID,Sullivan Graeme P.³,Rodrigues Daniel A.¹,Chonghaile Tríona Ní³,Griffith Darren M.¹²^ORCID

Affiliation:

1. Department of Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Ireland

2. SSPC, the Science Foundation Ireland Research Centre for Pharmaceuticals, Ireland

3. Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland

Abstract

We report the development of the first metallo-PROTAC, specifically a Pt-PROTAC that effectively degrades select Pt(ii)-binding proteins. Metallo-PROTACs will have important applications in identifying metal binding proteins and as chemotherapeutics.

Funder

Irish Cancer Society

Irish Research Council

Science Foundation Ireland

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC03340F

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