Catalytic asymmetric synthesis of quaternary trifluoromethyl α- to ε-amino acid derivatives via umpolung allylation/2-aza-Cope rearrangement-Reference-Cited by-同舟云学术

Catalytic asymmetric synthesis of quaternary trifluoromethyl α- to ε-amino acid derivatives via umpolung allylation/2-aza-Cope rearrangement

Published:2020 Issue:40 Volume:11 Page:10984-10990
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sun Xi-Shang¹²³⁴⁵,Wang Xing-Heng¹²³⁴⁵,Tao Hai-Yan¹²³⁴⁵,Wei Liang¹²³⁴⁵,Wang Chun-Jiang¹²³⁴⁵^ORCID

Affiliation:

1. Engineering Research Center of Organosilicon Compounds & Materials

2. Ministry of Education

3. College of Chemistry and Molecular Sciences

4. Wuhan University

5. Wuhan

Abstract

In this study, we developed an efficient Ir-catalyzed cascade umpolung allylation/2-aza-Cope rearrangement for the preparation of a variety of quaternary trifluoromethyl α-ε-amino acids in high yields with excellent enantioselectivities.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hubei Province

Project 211

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC04685J

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