Sulforaphane attenuates glycoprotein VI-mediated platelet mitochondrial dysfunction through up-regulating the cAMP/PKA signaling pathway <i>in vitro</i> and <i>in vivo</i>-Reference-Cited by-同舟云学术

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Sulforaphane attenuates glycoprotein VI-mediated platelet mitochondrial dysfunction through up-regulating the cAMP/PKA signaling pathway in vitro and in vivo

Published:2023 Issue:8 Volume:14 Page:3613-3629
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Zhou Xinyu¹,Huang Xinhui¹,Wu Chunting¹,Ma Yongjie¹,Li Weiqi¹,Hu Jinqiu¹,Li Rong¹,Ya Fuli¹²^ORCID

Affiliation:

1. Department of Nutrition, School of Public Health, Dali University, Dali, Yunnan Province 671000, China

2. Institute of Translational Medicine for Metabolic Diseases, Dali University, Dali, Yunnan Province 671000, China

Abstract

Treatment of SFN in human platelets or 12-week supplementation of SFN-enriched BSE in mice attenuates GPVI-mediated mitochondrial dysfunction, apoptosis and activation, which depends on decreasing PDE3A activity and up-regulation of the cAMP/PKA pathway.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D2FO03958C

Reference52 articles.

1. Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

2. Extracellular matrix proteins in the regulation of thrombus formation

3. Platelet GPVI (Glycoprotein VI) and Thrombotic Complications in the Venous System

4. The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation

5. Regulation of oxidized platelet lipidome: implications for coronary artery disease

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