Synthesis and characterization of high affinity fluorogenic α-synuclein probes-Reference-Cited by-同舟云学术

Synthesis and characterization of high affinity fluorogenic α-synuclein probes

Published:2020 Issue:24 Volume:56 Page:3567-3570
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Lengyel-Zhand Zsofia¹²³⁴⁵^ORCID,Ferrie John J.⁶³⁴⁵^ORCID,Janssen Bieneke¹²³⁴⁵^ORCID,Hsieh Chia-Ju¹²³⁴⁵,Graham Thomas¹²³⁴⁵,Xu Kui-ying¹²³⁴⁵,Haney Conor M.⁶³⁴⁵^ORCID,Lee Virginia M.-Y.⁷³⁴⁵,Trojanowski John Q.⁷³⁴⁵,Petersson E. James⁶³⁴⁵^ORCID,Mach Robert H.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Radiology

2. Perelman School of Medicine

3. University of Pennsylvania

4. Philadelphia

5. USA

6. Department of Chemistry

7. Department of Pathology and Laboratory Medicine, Perelman School of Medicine

Abstract

Fluorescent molecules are powerful tools for imaging α-synuclein pathology. Here, we demonstrate that benzofuranone derivatives have high affinity for α-synuclein and display different binding to α-synucleinopathies in post-mortem brain tissue.

Funder

National Institutes of Health

Michael J. Fox Foundation for Parkinson's Research

Parkinson's Disease Foundation

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/C9CC09849F

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