Substrate structure–activity relationships guide rational engineering of modular polyketide synthase ketoreductases-Reference-Cited by-同舟云学术

Substrate structure–activity relationships guide rational engineering of modular polyketide synthase ketoreductases

Published:2016 Issue:4 Volume:52 Page:792-795
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bailey Constance B.¹²³⁴,Pasman Marjolein E.¹²³⁴,Keatinge-Clay Adrian T.¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. University of Texas at Austin

3. Austin

4. USA

5. Department of Molecular Biosciences

Abstract

Structure–activity relationship studies guided stereocontrol engineering within a modular polyketide synthase ketoreductase to yield a more active enzyme whose reactivity can be explained through the Felkin–Anh model.

Funder

National Institutes of Health

Welch Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C5CC07315D

Reference32 articles.

1. Modern Aldol Methods for the Total Synthesis of Polyketides

2. Lithiation–Borylation Methodology and Its Application in Synthesis

3. Filling Gaps in Asymmetric Hydrogenation Methods for Acyclic Stereocontrol: Application to Chirons for Polyketide-Derived Natural Products

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Highly Stereoselective Biocatalytic One-Pot Synthesis of Chiral Saturated Oxygen Heterocycles by Integration of a Biosynthetic Heterocyclase into Multiple-Enzyme Cascades;ACS Catalysis;2024-08-23

2. Expanding the Application of Alcohol Dehydrogenases in Pharmaceutical Chemistry: A Focus on Piperidone Synthesis;ChemCatChem;2024-02-29

3. Synthesis of Biomimetic Thioesters for Studies of Ketoreductase Domains from the Biosynthesis of Cytotoxic Polyketides;Synlett;2023-11-22

4. Expanding the Utility of Bioinformatic Data for the Full Stereostructural Assignments of Marinolides A and B, 24- and 26-Membered Macrolactones Produced by a Chemically Exceptional Marine-Derived Bacterium;Marine Drugs;2023-06-20

5. Determination of enantiomeric excess and diastereomeric excess via optical methods. Application to α-methyl-β-hydroxy-carboxylic acids;Organic Chemistry Frontiers;2023