Linoleic acid metabolism activation in macrophages promotes the clearing of intracellular <i>Staphylococcus aureus</i>-Reference-Cited by-同舟云学术

Linoleic acid metabolism activation in macrophages promotes the clearing of intracellular Staphylococcus aureus

Published:2022 Issue:42 Volume:13 Page:12445-12460
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yan Bingpeng¹^ORCID,Fung Kingchun¹,Ye Sen²^ORCID,Lai Pok-Man¹,Wei Yuan Xin¹,Sze Kong-Hung¹,Yang Dan²³^ORCID,Gao Peng¹^ORCID,Kao Richard Yi-Tsun¹

Affiliation:

1. Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China

2. Morningside Laboratory for Chemical Biology and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China

3. Laboratory of Chemical Biology and Molecular Medicine, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, P. R. China

Abstract

Infected macrophages release signaling lipids (e.g., linoleic acid) and activate subsequent metabolic pathways to stimulate ROS generation that facilities intracellular bacteria killing, which may represent a novel mechanism of bacterial elimination.

Funder

Health and Medical Research Fund

Research Grants Council, University Grants Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC04307F

Reference60 articles.

1. Origins and Evolution of Antibiotic Resistance

2. Eradication of methicillin-resistantStaphylococcus aureusinfection by nanoliposomes loaded with gentamicin and oleic acid

3. Reactive Oxygen Species in Pathogen Clearance: The Killing Mechanisms, the Adaption Response, and the Side Effects

4. Palmitoleic Acid Isomer (C16:1Δ6) in Human Skin Sebum Is Effective against Gram-Positive Bacteria

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