Switching from ultrafast electron transfer to proton transfer in excited drug–protein complexes upon biotransformation-Reference-Cited by-同舟云学术

Switching from ultrafast electron transfer to proton transfer in excited drug–protein complexes upon biotransformation

Published:2022 Issue:33 Volume:13 Page:9644-9654
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tamarit Lorena¹²^ORCID,El Ouardi Meryem¹²,Lence Emilio³^ORCID,Andreu Inmaculada¹²^ORCID,González-Bello Concepción³^ORCID,Vayá Ignacio¹²^ORCID,Miranda Miguel A.¹²^ORCID

Affiliation:

1. Departamento de Química/Instituto de Tecnología Química UPV-CSIC, Universitat Politècnica de València, Camino de Vera s/n, 46022 València, Spain

2. Instituto de Investigación Sanitaria La Fe, Hospital Universitari i Politècnic La Fe, Avenida de Fernando Abril Martorell 106, 46026 Valencia, Spain

3. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain

Abstract

The photoinduced processes from the protein-bound GFT result in electron transfer, while those related with the photoactive metabolite GFT-MB induce excited state proton transfer to form phenolate-like excited species.

Funder

Ministerio de Ciencia e Innovación

Xunta de Galicia

Centro Singular de Investigación de Galicia

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC03257K

Reference47 articles.