Glycomimetics for the inhibition and modulation of lectins

Author:

Leusmann Steffen123ORCID,Ménová Petra4ORCID,Shanin Elena56ORCID,Titz Alexander123ORCID,Rademacher Christoph56ORCID

Affiliation:

1. Chemical Biology of Carbohydrates (CBCH), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, 66123 Saarbrücken, Germany

2. Department of Chemistry, Saarland University, 66123 Saarbrücken, Germany

3. Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, Germany

4. University of Chemistry and Technology, Prague, Technická 5, 16628 Prague 6, Czech Republic

5. Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria

6. Department of Microbiology, Immunobiology and Genetics, Max F. Perutz Laboratories, University of Vienna, Biocenter 5, 1030 Vienna, Austria

Abstract

Carbohydrates are essential mediators of many processes in health and disease. The development of glycomimetics as inhibitors and modulators of their lectin receptors has been a success story with numerous molecules reaching clinical stages.

Funder

H2020 European Research Council

Austrian Science Fund

Deutsche Forschungsgemeinschaft

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference710 articles.

1. A.Varki , R. D.Cummings , J. D.Esko , P.Stanley , G. W.Hart , M.Aebi , D.Mohnen , T.Kinoshita , N. H.Packer , J. H.Prestegard , R. L.Schnaar and P. H.Seeberger , Essentials of Glycobiology , Cold Spring Harbor Laboratory Press, Cold Spring Harbor (NY) , 4th edn, 2022

2. Invited Commentary: A calculation of all possible oligosaccharide isomers both branched and linear yields 1.05 × 1012 structures for a reducing hexasaccharide: the Isomer Barrier to development of single-method saccharide sequencing or synthesis systems

3. The Surface Coats of Animal Cells

4. The Bacterial Glycocalyx in Nature and Disease

5. Phosphoglycosylation: A new structural class of glycosylation?

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