Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation-Reference-Cited by-同舟云学术

Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation

Published:2016 Issue:5 Volume:7 Page:3325-3330
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tian Yuan¹²³⁴,Li Jingxu¹²³⁴,Zhao Hui¹²³⁴,Zeng Xiangze⁵⁶⁷⁸⁹,Wang Dongyuan¹²³⁴,Liu Qisong¹²³⁴,Niu Xiaogang¹⁰¹¹¹²¹³⁴,Huang Xuhui⁵⁶⁷⁸⁹,Xu Naihan¹⁴¹⁵¹⁶³⁴,Li Zigang¹²³⁴

Affiliation:

1. School of Chemical Biology and Biotechnology

2. Shenzhen Graduate School of Peking University

3. Shenzhen

4. China

5. Department of Chemistry

6. Center of Systems Biology and Human Health

7. School of Science and Institute for Advance Study

8. The Hong Kong University of Science and Technology

9. Hong Kong

10. College of Chemistry and Molecular Engineering

11. Beijing Nuclear Magnetic Resonance Center

12. Peking University

13. Beijing

14. Key Lab in Healthy Science and Technology

15. Division of Life Science

16. Shenzhen Graduate School of Tsinghua University

Abstract

A one component intramolecular thiol–yne macrocyclization is achieved upon UV irradiation to constrain short unprotected peptides into a helical conformation, providing rapid access to stapled peptides with satisfying functional group tolerance.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC00106H

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