2-Aminoimidazole facilitates efficient gene delivery in a low molecular weight poly(amidoamine) dendrimer-Reference-Cited by-同舟云学术

2-Aminoimidazole facilitates efficient gene delivery in a low molecular weight poly(amidoamine) dendrimer

Published:2018 Issue:24 Volume:16 Page:4464-4470
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Jing¹²³⁴⁵,Hu Xuefeng¹²³⁴⁵,Wang Dongli¹²³⁴⁵,Xie Cao¹²³⁴⁵,Lu Weiyue¹²³⁴⁵,Song Jie¹²³⁴⁵,Wang Ruifeng¹²³⁴⁵,Gao Chunli⁶⁷⁸⁹,Liu Min¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutics

2. School of Pharmacy

3. Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University)

4. Ministry of Education

5. Shanghai

6. Department of Otolaryngology-Head and Neck Surgery

7. Eye and ENT Hospital

8. Fudan University

9. P.R. China

Abstract

2-Aminoimidazole greatly improved the transfection efficiency of G2. It contributes to condensing DNA into small, monodisperse nanostructures, enhancing cellular penetration and endosome/lysosome escape.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00953H

Reference36 articles.

1. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery

2. The effect of fluorination on the transfection efficacy of surface-engineered dendrimers

3. Dendrimer type bio-reducible polymer for efficient gene delivery

4. Nonviral gene delivery systems: From simple transfection agents to artificial viruses

5. Synthetic DNA delivery systems

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